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June 16th, 2010

Dynamics and mechanisms of quantum dot nanoparticle cellular uptake

Abstract:
We explored the kinetics and mechanism of cellular uptake of QDs with different surface coatings in two human mammary cells.

No cytotoxicity was observed in cells incubated with 0.8 nM of QDs for a period of 72h.

Conclusions: The findings presented here provide information on the mechanism of QD endocytosis that could be exploited to reduce non-specific targeting, thereby improving specific targeting of QDs in cancer diagnosis and treatment applications. These findings are also important in understanding the cytotoxicity of nanomaterials and in emphasizing the importance of strict environmental control of nanoparticles.

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