Home > Press > Mathematical nanotoxicoproteomics: Quantitative characterization of effects of multi-walled carbon nanotubes: This research article by Dr. Subhash Basak et al. will be published in Current Computer-Aided Drug Design, Volume 12, 2016
 |
Abstract:
Various applications of nanosubstances in industrial and consumer goods sectors are becoming increasingly common because of their useful chemical and physical properties. Therefore the development of methods for the assessment of potential hazards to human and ecological health posed by increased exposure to nanosubstances is necessary.
Mathematical nanotoxicoproteomics: Quantitative characterization of effects of multi-walled carbon nanotubes: This research article by Dr. Subhash Basak et al. will be published in Current Computer-Aided Drug Design, Volume 12, 2016
Sharjah, U.A.E. | Posted on September 2nd, 2016In this paper, mathematical models were developed to characterize proteomics patterns of Caco-2/HT29-MTX cells exposed for three and twenty four hours to two kinds of important nanoparticles: multi-walled carbon nanotubes (MWCNT) and TiO2 nanobelts (TiO2-NB). For each nanosubstance, cells were exposed to two concentrations of the material before carrying out proteomics analyses: 10 μg and 100 μg. In each case over 3,000 proteins were identified. Such data generated by the omics sciences fall in the 'Big Data' realm. Visualization of such massive data is a daunting task and methods are needed to simplify such data analysis. A mathematically based similarity index, which measures the changes in abundances of cellular proteins that are strongly affected by exposure to the nanosubstances, was used to characterize toxic effects of the nanomaterials. We identified 8 and 25 proteins, which are most highly perturbed by MWCNT and TiO2-NB, respectively. These proteins may be responsible for a specific response of the exposed cells to the nanoparticles. Furthermore, a set pf 14 proteins were affected by either of the two nanoparticles. These proteins likely reflect a non-specific toxic response of the cells. The similarity methods proposed in this paper may be useful in the management and visualization of the large amount of data generated by proteomics technologies while assessing nanomaterial safety.
####
For more information, please click here
Contacts:
Faizan ul Haq
Copyright © Bentham Science Publishers
If you have a comment, please Contact us.Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.
Bookmark:
| Related Links |
For more information about the article, please visit:
| Related News Press |
News and information
Closing the gaps — MXene-coating filters can enhance performance and reusability February 28th, 2025
Rice researchers harness gravity to create low-cost device for rapid cell analysis February 28th, 2025
Nanotubes/Buckyballs/Fullerenes/Nanorods/Nanostrings
Chainmail-like material could be the future of armor: First 2D mechanically interlocked polymer exhibits exceptional flexibility and strength January 17th, 2025
Innovative biomimetic superhydrophobic coating combines repair and buffering properties for superior anti-erosion December 13th, 2024
Discoveries
Closing the gaps — MXene-coating filters can enhance performance and reusability February 28th, 2025
Rice researchers harness gravity to create low-cost device for rapid cell analysis February 28th, 2025
Materials/Metamaterials/Magnetoresistance
Chainmail-like material could be the future of armor: First 2D mechanically interlocked polymer exhibits exceptional flexibility and strength January 17th, 2025
Enhancing transverse thermoelectric conversion performance in magnetic materials with tilted structural design: A new approach to developing practical thermoelectric technologies December 13th, 2024
FSU researchers develop new methods to generate and improve magnetism of 2D materials December 13th, 2024
Announcements
Closing the gaps — MXene-coating filters can enhance performance and reusability February 28th, 2025
Rice researchers harness gravity to create low-cost device for rapid cell analysis February 28th, 2025
Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers/Posters
Leading the charge to better batteries February 28th, 2025
Quantum interference in molecule-surface collisions February 28th, 2025
New ocelot chip makes strides in quantum computing: Based on "cat qubits," the technology provides a new way to reduce quantum errors February 28th, 2025
Environment
SMART researchers pioneer first-of-its-kind nanosensor for real-time iron detection in plants February 28th, 2025
Nanoparticle bursts over the Amazon rainforest: Rainfall induces bursts of natural nanoparticles that can form clouds and further precipitation over the Amazon rainforest November 8th, 2024
New method in the fight against forever chemicals September 13th, 2024
Industrial
Quantum interference in molecule-surface collisions February 28th, 2025
Boron nitride nanotube fibers get real: Rice lab creates first heat-tolerant, stable fibers from wet-spinning process June 24th, 2022
Nanotubes: a promising solution for advanced rubber cables with 60% less conductive filler June 1st, 2022
Protective equipment with graphene nanotubes meets the strictest ESD safety standards March 25th, 2022
Safety-Nanoparticles/Risk management
Closing the gaps — MXene-coating filters can enhance performance and reusability February 28th, 2025
Tests find no free-standing nanotubes released from tire tread wear September 8th, 2023
 |
||
 |
||
| The latest news from around the world, FREE | ||
 |
||
|
|
||
| Premium Products | ||
 |
||
|
Only the news you want to read!
Learn More |
||
 |
||
|
Full-service, expert consulting
Learn More |
||
|
|
||