Home > Press > Performance of Polymeric Nanoparticles as Gene Carriers Studied by Iranian, Dutch Scientists
Abstract:
A research group consisting of researchers from Royan Biotechnology Research Institute, Tehran and Isfahan Universities of Medical Sciences in cooperation with their colleagues from Medical Research Institute of Utrecht University, Netherlands, studied the performance of a type of polymer as a gene carrier.
Performance of Polymeric Nanoparticles as Gene Carriers Studied by Iranian, Dutch Scientists
Tehran, Iran | Posted on October 9th, 2015The carrier is able to create nanometric particles after being added to the gene pieces and it has been studied at laboratorial scale. It also showed appropriate performance in comparison with the existing commercial samples.
This research deals with the evaluation in vitro gene delivery efficiency of poly [N-(2-aminoethyl) ethylene-imine] (PAEEI). However, the final purpose of the research is to study in vivo gene delivery properties of the polymer. The polymer had been synthesized in the previous studies, but no report is yet available about its gene delivery properties.
The application of virus gene carriers is very efficient but there are limitations in the applications due to the malfunction in their immunity after continuous consumptions. Therefore, non-virus delivery systems have been of more interest in recent years. Cationic polymers, inorganic nanoparticles, lipid nanoparticles, liposomes, and peptides are among the non-virus gene delivery systems.
The pre-cursor monomer was firstly synthesized in this research. Then, gene delivery properties and the toxicity of the monomer were studied on living cells at laboratorial scale. In the end, it was concluded that the suggested polymer is comparable to and can replace the standard sample.
Results of the research have been published in Journal of Pharmacy & Pharmaceutical Sciences, vol. 17, issue 4, 2014, pp. 461-474.
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