Nanotechnology Now - Press Release: New Malvern data demonstrate monoclonal antibody characterization using the Viscotek SEC-MALS 20

Home > Press > New Malvern data demonstrate monoclonal antibody characterization using the Viscotek SEC-MALS 20

Abstract:
Malvern Instruments has posted a new application note demonstrating the use of the company's Viscotek SEC-MALS 20 multi angle light scattering (MALS) detector for size exclusion chromatography (SEC) in the analysis of monoclonal antibodies. The application note, ‘Molecular weight measurements of an antibody using Viscotek SEC-MALS 20', reports experimental data for the analysis of aggregates within monoclonal antibody formulations and can be freely downloaded at www.malvern.com/secmalslaunch

New Malvern data demonstrate monoclonal antibody characterization using the Viscotek SEC-MALS 20

Malvern, UK | Posted on November 27th, 2013

Monoclonal antibodies are being targeted for use in a growing range of therapeutic applications. Measuring the molecular weight of the protein, monomer, oligomers and aggregates within the sample and in formulations is an important part of assessing their safety and efficacy as drugs. Light scattering techniques allow the measurement of absolute molecular weight without relying on potentially inaccurate calibration methods, with MALS an established technology within the industry.

When added to a GPC/SEC chromatography system, the new Viscotek SEC-MALS 20 delivers market-leading MALS detector performance with high accuracy, even at high molecular weights. Its launch makes the Malvern Instruments Viscotek light scattering detector range the broadest available, allowing the company to offer unbiased, optimized solutions for any GPC/SEC application. To find out more about the Viscotek SEC-MALS 20 visit the Malvern Instruments website at www.malvern.com/secmalslaunch

Malvern, Malvern Instruments, Viscotek are registered trademarks of Malvern Instruments Ltd

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Malvern provides the materials and biophysical characterization technology and expertise that enables scientists and engineers to understand and control the properties of dispersed systems. These systems range from proteins and polymers in solution, particle and nanoparticle suspensions and emulsions, through to sprays and aerosols, industrial bulk powders and high concentration slurries. Used at all stages of research, development and manufacturing, Malvern’s materials characterization instruments provide critical information that helps accelerate research and product development, enhance and maintain product quality and optimize process efficiency.

Our products reflect Malvern’s drive to exploit the latest technological innovations and our commitment to maximizing the potential of established techniques. They are used by both industry and academia, in sectors ranging from pharmaceuticals and biopharmaceuticals to bulk chemicals, cement, plastics and polymers, energy and the environment.

Malvern systems are used to measure particle size, particle shape, zeta potential, protein charge, molecular weight, mass, size and conformation, rheological properties and for chemical identification, advancing the understanding of dispersed systems across many different industries and applications.

Headquartered in Malvern, UK, Malvern Instruments has subsidiary organizations in all major European markets, North America, Mexico, China, Japan and Korea, a joint venture in India, a global distributor network and applications laboratories around the world.
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