Home > Press > Controlled Drug Delivery with Organic-Inorganic Nanohybrids
Abstract:
Iranian researchers at Malayer University succeeded in the coprecipitated synthesis of zinc-aluminum-hydroxide nanolayers and used them in drug delivery systems.
Controlled Drug Delivery with Organic-Inorganic Nanohybrids
Iran | Posted on December 13th, 2010"This nanohybrid is classified as a nano-layer structure. Various useful factors such as medicine, magnetic materials, polymers, etc can be loaded on the space between the layers," Mohammad Yeganeh Qotbi, member of the Scientific Board of Ceramic and Material Engineering Group of Malayer University, told Iran Nanotechnology Initiative Council.
"The obtained compound will have both the properties of the based material and the inserted objects at the same time."
Elaborating on the procedure of the study, he reiterated, "In our research, we inserted gallic acid anion, which is an anti-carcinogenic, anti oxidation, anti-mutation, and anti-microbial agent, into the space between the based layers at a nano scale. Then we studied drug release from the space between the based layers in various aqueous environments, and we created the kinetic model for the release."
"In this research the zinc-aluminium-hydroxide-based nanolayers were synthesized through a coprecipitation method. There are nitrate ions between the layers. In the next stage, gallic acid anions were replaced by nitrate ions through an ion exchange process, and the organic-inorganic nanohybrid compound was formed. Then, the drug was released from the obtained nanohybrids in pure aqueous and ionic environments," Yeganeh Qotbi said.
According to Dr Yeganeh Qotbi, among the advantages of this research, mention can be made of the simplicity of the synthesis procedure, reasonable price of raw materials, the possibility of loading high amount of drug, long releasing period, and harmlessness of the base material, which is gradually absorbed by human's body.
The preliminary steps of the research were taken in University Putra in Malaysia, and it was completed in University of Malayer.
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