Nanotechnology Now - Press Release: Malvern’s Zetasizer APS uses standard microwell plates for fully automated DLS measurement

Home > Press > Malvern’s Zetasizer APS uses standard microwell plates for fully automated DLS measurement

Abstract:
Malvern's new Zetasizer Auto Plate Sampler (APS) is designed primarily for protein specialists, delivering fully automated protein and nanoparticle size measurements using dynamic light scattering (DLS), for improved productivity. Unlike other systems, the Zetasizer APS does not require micro well plates to be flat-bottomed or have specific optical properties. A unique sample handling process makes it compatible with virtually all commercially available microwell plates. Automated measurement procedures using industry standard 96- or 384-well plates enable users to simply insert a sample plate and press "start".

Malvern’s Zetasizer APS uses standard microwell plates for fully automated DLS measurement

Malvern, UK | Posted on January 22nd, 2009

The Zetasizer APS delivers accurate and repeatable protein size and molecular weight data with no compromise in data quality due to automating the measurements. Only 20μl of sample is used, and this is returned to the same well for use for other characterization techniques. Programmable dual temperature controls maintain optimal conditions for samples in the well plate while enabling automated temperature trend measurements for melting point determination, protein purity or shelf-life investigations for example.

DLS data can be used to solve application problems in bioprocessing, drug target development and protein therapeutics. DLS measures the thermal diffusion of proteins and nanoparticles in solution, and uses this property to determine an absolute hydrodynamic size. This technique is especially sensitive to the presence of aggregates, and their proportion as a function of solvent and buffer conditions can also be determined, speeding development of the protein's optimum environmental conditions.

The Zetasizer APS from Malvern Instruments allows quick and easy investigation of a protein's condition at different stages of the purification process, and at later stages of formulation under a range of environmental conditions. User friendly software and a worldwide customer support network complete the package, making this system an ideal solution for protein characterization.

Malvern, Malvern Instruments and Zetasizer are registered trademarks of Malvern Instruments Ltd

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About Malvern Instruments Ltd
Malvern Instruments provides a range of complementary materials characterization tools that deliver inter-related measurements reflecting the complexities of particulates and disperse systems, nanomaterials and macromolecules. Analytical instruments from Malvern are used in the characterization of a wide variety of materials, from industrial bulk powders to the latest nanomaterials and delicate macromolecules. A broad portfolio of innovative technologies is combined with intelligent, user-friendly software. These systems deliver industrially relevant data enabling our customers to make the connection between micro (such as particle size) and macro (bulk) material properties (rheology) and chemical composition (chemical imaging).

Particle size distribution, particle shape information, zeta potential, molecular weight, chemical composition, and bulk materials properties can all be determined with instruments from the Malvern range. The company’s laboratory, at-line, on-line and in-line solutions are proven in sectors as diverse as cement production and pharmaceutical drug discovery.

Headquartered in Malvern, UK, Malvern Instruments has subsidiary organizations in all major European markets, North America, China, Korea and Japan, a joint venture in India, a global distributor network and applications laboratories around the world.

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Contacts:
For press information, please contact:
Trish Appleton
Kapler Communications
Knowledge Centre
Wyboston Lakes
Great North Road
Wyboston
Bedfordshire
MK44 3BY, UK
Tel: +44 (0)1480 479280;
Fax: +44 (0)1480 470343

USA contact:
Marisa Fraser
Malvern Instruments Inc.
117 Flanders Road
Westborough
MA 01581-1042 USA
Tel: +1 508 768 6400
Fax: +1 508 768 6403

Please send sales enquiries to:
Alison Vines
Malvern Instruments Ltd
Enigma Business Park
Grovewood Road
Malvern
Worcestershire
WR14 1XZ UK
Tel: +44 (0) 1684 892456;
Fax: +44 (0) 1684 892789