Home > Press > Nanobiotix presented new clinical and pre-clinical data confirming NBTXR3’s significant potential role in Immuno-Oncology at SITC Annual Meeting
Abstract:
· NBTXR3 activated by radiotherapy induces a significant adaptive immune pattern versus radiotherapy alone in patients with soft tissue sarcoma
· Patients treated with NBTXR3 and radiotherapy show a marked increase of PD1 and CD8 infiltration
· Preclinical data on different animal models confirm broad potential of NBTXR3 as a primer of the immune response
· Strong data to support the rational for the upcoming clinical trial in combination with check point inhibitors.
NANOBIOTIX NANOBIOTIX(Euronext: NANO – ISIN: FR0011341205), a late clinical-stage nanomedicine company pioneering new approaches to the treatment of cancer, recently presented positive clinical and preclinical data from the ongoing immuno-oncology programs. These data were presented at the 32nd Annual Meeting of the Society for Immunotherapy of Cancer (SITC), held from November 8 to 12, 2017 in National Harbor, Maryland, USA.
Nanobiotix’s lead product, NBTXR3, has a universal physical mode of action which is designed for the local destruction of tumors. In addition to the physical destruction of cancer cells, recently published data suggested that NBTXR3 generates immunogenic cell death which could trigger a specific immune response to attack tumors.
The new clinical data and pre-clinical data indicate that NBTXR3 could play a key role in oncology and could become a backbone of immuno-oncology.
The data Nanobiotix recently presented at SITC from its immuno-oncology programs included:
“Antitumor immunity in patients with locally soft tissue sarcoma treated with hafnium oxide nanoparticles and radiation therapy”[i] -- P 412
In this study, tumors from the ongoing two-arm Phase II/III clinical trial were examined both pre- and post-treatment in patients with locally advanced soft tissue sarcoma who had received either NBTXR3 with radiotherapy (more than 10 patients) or radiotherapy alone (more than 10 patients).
The results observed in the post-treatment examination of patients who received both NBTXR3 and radiotherapy showed a significant increase of CD8+ T cells and a marked increase of CD3+, PD-1 and CD103+ immune cell infiltration. In contrast, there was no difference observed between pre- and post-treatment examination when patients received radiotherapy alone.
Furthermore, a functional analysis of genes up-regulated in NBTXR3 plus Radiotherapy arm showed an enrichment of cytokines, immune checkpoints, T cell activation, and dendritic/macrophages markers.
These promising data confirm that NBTXR3 induces a specific adaptive immune pattern and brings substantial changes to the tumor immune profile in patients with soft tissue sarcoma. As such, it may convert the tumor immunologically and be effectively combined with immunotherapeutic agents across oncology.
These data strengthen the relevance of using NBTXR3 in combination with immune checkpoint inhibitors. In September 2017, Nanobiotix announced the Company’s plan to conduct its first clinical trial with NBTXR3 in combination with immune checkpoint inhibitors in the U.S., with a multi-arm trial targeting a sub-population of advanced lung, and head and neck cancer patients.
“Transforming immunologically ‘cold’ tumor into ‘hot’ tumor with hafnium oxide nanoparticles and radiation therapy”[ii] -- P 413
These in vivo pre-clinical studies explored the ability of NBTXR3 to bring substantial immune cell infiltrations in colorectal cancer and breast cancer models, and convert immunologically “cold” tumors into “hot” tumors.
In mice bearing CT26 tumors (murine colorectal cancer cells), a marked increase of cytokine content and immune cell infiltrates was observed with NBTXR3 and radiotherapy compared to radiotherapy alone.
In mice inoculated with 4T1 cells (murine breast cancer model) previously treated with NBTXR3 and radiotherapy, a marked increase of CD8+ was observed in tumors when compared to those in mice inoculated with 4T1 cells treated only with radiotherapy.
Data generated from colorectal and breast cancer tumor models suggest that NBTXR3 triggers immunogenic conversion of the tumor microenvironment regardless of the molecular characteristics of the tumor. These data confirm the broad potential of NBTXR3 as a primer of the immune response.
***
About NANOBIOTIX’s immuno-oncology research program
Many IO combination strategies focus on ‘priming’ the tumor, which is now becoming a prerequisite of turning a “cold” tumor into a “hot” tumor. Compared to other modalities that could be used for priming the tumor, NBTXR3 could have a number of advantages: the physical and universal mode of action that could be used widely across oncology, the one-time local injection and good fit within existing medical practice already used as a basis for cancer treatment, as well as a very good chronic safety profile and well-established manufacturing process.
After more than 18 months of development, the Company presented preclinical proof of concept demonstrating that NBTXR3 actively stimulates the host immune system to attack tumor cells.
Recently, Nanobiotix presented new translational data. Taken together, these non-clinical and preliminary clinical results confirm that NBTXR3 plus radiotherapy could efficiently prime an adaptive antitumor immune response, turning “cold” tumors in “hot” tumors. Additionally, these results suggest that the physically-induced response and subsequent immune activation triggered by the NBTXR3 treatment could be generic.
Results suggests that NBTXR3 with radiotherapy could transform tumors into an effective in situ vaccine, opening up very promising perspectives in the treatment of local cancer and metastases.
On top of the Company’s core development activities, these findings could open new collaborations for NBTXR3 through combinations with other immuno-oncology drugs.
In September 2017, Nanobiotix announced its intention to start a new trial in the company’s immuno-oncology (IO) program. The trial is aimed at expanding the potential of NBTXR3 to recurrent and metastatic disease.
####
About Nanobiotix
Nanobiotix (Euronext: NANO / ISIN: FR0011341205) is a late clinical-stage nanomedicine company pioneering novel approaches for the treatment of cancer. The Company’s first-in-class, proprietary technology, NanoXray, enhances radiotherapy energy with a view to providing a new, more efficient treatment for cancer patients.
NanoXray products are compatible with current radiotherapy treatments and are meant to treat potentially a wide variety of solid tumors including soft tissue sarcoma, head and neck cancers, liver cancers, prostate cancer, breast cancer, glioblastoma, etc., via multiple routes of administration.
NBTXR3 is being evaluated in: soft tissue sarcoma (STS), head and neck cancers, prostate cancer, and liver cancers (primary and metastases). Additionally, head and neck cancer and rectal cancer trials led by Nanobiotix’s Taiwanese partner, PharmaEngine, are underway in the Asia Pacific region. The Company filed in August 2016 for market approval (CE Marking) in Europe for its lead product NBTXR3.
In 2016 the Company started a new preclinical research program in Immuno-oncology with its lead product NBTXR3, which could have the potential to bring a new dimension to cancer immunotherapies.
Nanobiotix is listed on the regulated market of Euronext in Paris (ISIN: FR0011341205, Euronext ticker: NANO, Bloomberg: NANO: FP). The Company’s Headquarters is based in Paris, France, with a U.S. affiliate in Cambridge, MA.
For more information, please click here
Contacts:
Nanobiotix
Sarah Gaubert
Director, Communications & Public Affairs
+33 (0)1 40 26 07 55
/
Noël Kurdi
Director, Investor Relations
+1 (646) 241-4400
/
Media relations
France - Springbok Consultants
Marina Rosoff
+33 (0)6 71 58 00 34
United States – RooneyPartners
Marion Janic
+1 (212) 223-4017
Copyright © Nanobiotix
If you have a comment, please Contact us.Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.
Related News Press |
News and information
Beyond wires: Bubble technology powers next-generation electronics:New laser-based bubble printing technique creates ultra-flexible liquid metal circuits November 8th, 2024
Nanoparticle bursts over the Amazon rainforest: Rainfall induces bursts of natural nanoparticles that can form clouds and further precipitation over the Amazon rainforest November 8th, 2024
Nanotechnology: Flexible biosensors with modular design November 8th, 2024
Exosomes: A potential biomarker and therapeutic target in diabetic cardiomyopathy November 8th, 2024
Cancer
The mechanism of a novel circular RNA circZFR that promotes colorectal cancer progression July 5th, 2024
New micromaterial releases nanoparticles that selectively destroy cancer cells April 5th, 2024
Govt.-Legislation/Regulation/Funding/Policy
New discovery aims to improve the design of microelectronic devices September 13th, 2024
Physicists unlock the secret of elusive quantum negative entanglement entropy using simple classical hardware August 16th, 2024
Single atoms show their true color July 5th, 2024
Nanomedicine
Exosomes: A potential biomarker and therapeutic target in diabetic cardiomyopathy November 8th, 2024
Unveiling the power of hot carriers in plasmonic nanostructures August 16th, 2024
Announcements
Nanotechnology: Flexible biosensors with modular design November 8th, 2024
Exosomes: A potential biomarker and therapeutic target in diabetic cardiomyopathy November 8th, 2024
Turning up the signal November 8th, 2024
Nanofibrous metal oxide semiconductor for sensory face November 8th, 2024
Nanobiotechnology
Exosomes: A potential biomarker and therapeutic target in diabetic cardiomyopathy November 8th, 2024
The mechanism of a novel circular RNA circZFR that promotes colorectal cancer progression July 5th, 2024
The latest news from around the world, FREE | ||
Premium Products | ||
Only the news you want to read!
Learn More |
||
Full-service, expert consulting
Learn More |
||