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Developing a potential new treatment for Parkinson's gets a boost from nanoparticles.

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Abstract:
As baby boomers age, the number of people diagnosed with Parkinson's disease is expected to increase. Patients who develop this disease usually start experiencing symptoms around age 60 or older. Currently, there's no cure, but scientists are reporting a novel approach that reversed Parkinson's-like symptoms in rats. Their results, published in the journal ACS Nano, could one day lead to a new therapy for human patients.

Nanoparticle drug reverses Parkinson's-like symptoms in rats

Washington, DC | Posted on April 22nd, 2015

Rajnish Kumar Chaturvedi, Kavita Seth, Kailash Chand Gupta and colleagues from the CSIR-Indian Institute of Toxicology Research note that among other issues, people with Parkinson's lack dopamine in the brain. Dopamine is a chemical messenger that helps nerve cells communicate with each other and is involved in normal body movements. Reduced levels cause the shaking and mobility problems associated with Parkinson's. Symptoms can be relieved in animal models of the disease by infusing the compound into their brains. But researchers haven't yet figured out how to safely deliver dopamine directly to the human brain, which is protected by something called the blood-brain barrier that keeps out pathogens, as well as many medicines. Chaturvedi and Gupta's team wanted to find a way to overcome this challenge.

The researchers packaged dopamine in biodegradable nanoparticles that have been used to deliver other therapeutic drugs to the brain. The resulting nanoparticles successfully crossed the blood-brain barrier in rats, released its dopamine payload over several days and reversed the rodents' movement problems without causing side effects.

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The authors acknowledge funding from the Indian Department of Science and Technology as Woman Scientist and Ramanna Fellow Grant, and the Council of Scientific and Industrial Research (India).

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About American Chemical Society
The American Chemical Society is a nonprofit organization chartered by the U.S. Congress. With more than 158,000 members, ACS is the world's largest scientific society and a global leader in providing access to chemistry-related research through its multiple databases, peer-reviewed journals and scientific conferences. Its main offices are in Washington, D.C., and Columbus, Ohio.

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Contacts:
Michael Bernstein

202-872-6042

Rajnish Kumar Chaturvedi, Ph.D.
Developmental Toxicology Division, Systems Toxicology Group
CSIR-Indian Institute of Toxicology Research (CSIR-IITR)
Lucknow 226001, India
Phone: +91-522-2228227/+91-9450418445

or
Kavita Seth, Ph.D.
Developmental Toxicology Division, Systems Toxicology Group
CSIR-Indian Institute of Toxicology Research (CSIR-IITR)
Lucknow 226001, India
Phone: +91-522-2228227/+91-9451380653

or
Kailash Chand Gupta, Ph.D.
CSIR-Institute of Genomics & Integrative Biology (CSIR-IGIB)
Delhi 110007, India
Phone: +91-522-2620106/+91-8800994239