Nanotechnology Now

Our NanoNews Digest Sponsors
Heifer International



Home > Press > Nanoparticles at specific temperature stimulate antitumor response: Dartmouth researchers identify precise heat to boost immune system against cancer tumors

Abstract:
Seeking a way to stimulate antitumor responses via the immune system, Steven Fiering, PhD, of Norris Cotton Cancer Center at Dartmouth, has identified the precise temperature that results in a distinct body-wide antitumor immune response that resists metastatic disease. Fiering's team published the research in the paper "Local Hyperthermia Treatment of Tumors Induces CD8+ T Cell-Mediated Resistance Against Distal and Secondary Tumors," which appeared in Nanomedicine: Nanotechnology, Biology and Medicine.

Nanoparticles at specific temperature stimulate antitumor response: Dartmouth researchers identify precise heat to boost immune system against cancer tumors

Hanover, NH | Posted on April 14th, 2015

"Mild hyperthermia treatment of an identified tumor, prior to surgery to remove the tumor, shows excellent promise to strengthen the antitumor response and help stop metastatic disease," explained Fiering.

Among the many options for cancer treatment pursued by science, immunotherapy is a contemporary focus. The immune system recognizes and usually eliminates small tumors, but other tumors become clinical problems and are known to block the antitumor tendencies with a natural system for immunosuppression. Recently, scientists have worked to learn how to reverse this tumor-mediated immunosuppression. In addition, phagocytes (key actors in immunosuppression and immunostimulation and that quickly take up nanoparticles) have provided options for new strategies. Fierings's studies were done in mice with a melanoma tumor model, and began with inserting iron nanoparticles directly into the tumors while applying an alternating magnetic field to heat the nanoparticles evenly and at precise temperatures.

"While it's easy to apply enough heat to destroy the tumor, that sort of thermal ablation does not have the result we were looking for, which was to stimulate a systemic immune response to eliminate metastatic disease," said Fiering. "Looking at temperature variables, we learned that at precisely 43 degrees centigrade, the systemic immune response goes into action. Doing this safely is a potent treatment approach that can stimulate the immune system to fight untreated metastatic tumors."

Fiering utilized Dartmouth's Shared Resources including the Transgenic Mouse Resource to do mouse manipulations. Colleague P. Jack Hoopes of Dartmouth's Thayer School of Engineering provided the vitally important alternating magnetic field equipment. The Dartmouth Shared Resources are open to outside investigators by arrangement.

Using Norris Cotton Cancer Center's team science approach, Fiering and Hoopes look forward to joint studies testing the systemic immune response to nanoparticle treatment in dogs with melanoma. As in humans, melanoma is frequently metastatic and fatal for dogs. If the systemic immune response can be shown to prevent metastatic disease in dogs, it will be ready to develop for human clinical trials.

###

Fiering is Professor of Microbiology & Immunology, and of Genetics, at Dartmouth's Geisel School of Medicine. His work in cancer is facilitated by Dartmouth's Norris Cotton Cancer Center where he is a member of the Molecular Therapeutic Research Program.

Support for "Local Hyperthermia Treatment of Tumors Induces CD8+ T Cell-Mediated Resistance Against Distal and Secondary Tumors" was provided by the Dartmouth Center for Nanotechnology Excellence, National Institutes of Health grant 1 U54 CA151662, Center for Molecular, Cellular, and Translational Immunological Research grant NIGMS P20 RR15639, Norris Cotton Cancer Center Support Grant P30 CA023108 and Dartmouth Immunobiology of Myeloid and Lymphoid Cells grant 5T32A1007363-22.

####

About Geisel School of Medicine at Dartmouth
Norris Cotton Cancer Center combines advanced cancer research at Dartmouth and the Geisel School of Medicine with patient-centered cancer care provided at Dartmouth-Hitchcock Medical Center in Lebanon, NH, at Dartmouth-Hitchcock regional locations in Manchester, Nashua, and Keene, NH, and St. Johnsbury, VT, and at 12 partner hospitals throughout New Hampshire and Vermont. It is one of 41 centers nationwide to earn the National Cancer Institute's "Comprehensive Cancer Center" designation. Learn more about Norris Cotton Cancer Center research, programs, and clinical trials online at cancer.dartmouth.edu.

For more information, please click here

Contacts:
Kirk Cassels

603-653-6177

Copyright © Geisel School of Medicine at Dartmouth

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

Cancer

Ben-Gurion University of the Negev researchers several steps closer to harnessing patient's own T-cells to fight off cancer June 6th, 2025

News and information

INRS and ELI deepen strategic partnership to train the next generation in laser science:PhD students will benefit from international mobility and privileged access to cutting-edge infrastructure June 6th, 2025

Electrifying results shed light on graphene foam as a potential material for lab grown cartilage June 6th, 2025

Quantum computers simulate fundamental physics: shedding light on the building blocks of nature June 6th, 2025

A 1960s idea inspires NBI researchers to study hitherto inaccessible quantum states June 6th, 2025

Govt.-Legislation/Regulation/Funding/Policy

INRS and ELI deepen strategic partnership to train the next generation in laser science:PhD students will benefit from international mobility and privileged access to cutting-edge infrastructure June 6th, 2025

Electrifying results shed light on graphene foam as a potential material for lab grown cartilage June 6th, 2025

Institute for Nanoscience hosts annual proposal planning meeting May 16th, 2025

Rice researchers harness gravity to create low-cost device for rapid cell analysis February 28th, 2025

Nanomedicine

Ben-Gurion University of the Negev researchers several steps closer to harnessing patient's own T-cells to fight off cancer June 6th, 2025

Cambridge chemists discover simple way to build bigger molecules – one carbon at a time June 6th, 2025

Electrifying results shed light on graphene foam as a potential material for lab grown cartilage June 6th, 2025

Self-propelled protein-based nanomotors for enhanced cancer therapy by inducing ferroptosis June 6th, 2025

Discoveries

Researchers unveil a groundbreaking clay-based solution to capture carbon dioxide and combat climate change June 6th, 2025

Cambridge chemists discover simple way to build bigger molecules – one carbon at a time June 6th, 2025

Electrifying results shed light on graphene foam as a potential material for lab grown cartilage June 6th, 2025

A 1960s idea inspires NBI researchers to study hitherto inaccessible quantum states June 6th, 2025

Announcements

INRS and ELI deepen strategic partnership to train the next generation in laser science:PhD students will benefit from international mobility and privileged access to cutting-edge infrastructure June 6th, 2025

Electrifying results shed light on graphene foam as a potential material for lab grown cartilage June 6th, 2025

Quantum computers simulate fundamental physics: shedding light on the building blocks of nature June 6th, 2025

A 1960s idea inspires NBI researchers to study hitherto inaccessible quantum states June 6th, 2025

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers/Posters

Cambridge chemists discover simple way to build bigger molecules – one carbon at a time June 6th, 2025

Electrifying results shed light on graphene foam as a potential material for lab grown cartilage June 6th, 2025

Quantum computers simulate fundamental physics: shedding light on the building blocks of nature June 6th, 2025

A 1960s idea inspires NBI researchers to study hitherto inaccessible quantum states June 6th, 2025

Grants/Sponsored Research/Awards/Scholarships/Gifts/Contests/Honors/Records

Researchers uncover strong light-matter interactions in quantum spin liquids: Groundbreaking experiment supported by Rice researcher reveals new insights into a mysterious phase of quantum matter December 13th, 2024

New discovery aims to improve the design of microelectronic devices September 13th, 2024

Physicists unlock the secret of elusive quantum negative entanglement entropy using simple classical hardware August 16th, 2024

Atomic force microscopy in 3D July 5th, 2024

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project