Home > Press > Iranian Chemists Build Smart Armored Nanocarriers
Abstract:
Iranian chemical researchers used nanotechnology to produce smart nanogels with active targeting capability.
Iranian Chemists Build Smart Armored Nanocarriers
Tehran, Iran | Posted on March 16th, 2014Acid folic was used in the production of the nanogel as targeting agent in drug delivery. The nanogel can be used in the treatment of cancer as a stable nanocarrier.
Stability of nanocarriers is an important issue in target delivery mechanisms. Most of nanocarriers, due to their instability, release considerable amount of drug in healthy tissues before reaching the desired tissue, and they are free of drug when they reach the targeted tissue.
There are three different layers in the nanocarrier synthesized in this research: hydrophobic core made of polycaprolactone, which is filled with non-soluble or low-soluble anticancer drug in water, pH-sensitive layer made of amino ester, and finally the formation of nanogel and bond between targeting ligands such as folic acid and the hydrophilic shell made of polyethylene glycol as the stabilizing agent and the agent to prevent proteins existing in blood to accumulate on nanocarriers.
The middle layer formed in nanocarrier prevents its decomposition in thin aqueous media and plays the role of armor for the nanocarrier because of its networking ability and stabilization of copolymers. The amino ester structure of the layer possesses amine groups, and when they are protonized in acidic environment of the cancer cell, the structure causes repulsion among the chains of the layer, and it speeds up the release of the drug. Therefore, the nanocarriers are known as smart armored nanocarriers, and they will act highly effectively in the treatment of cancer after carrying out more research and passing in-vivo tests.
Results of the research have been published in details in European Journal of Medicinal Chemistry, vol. 73, issue 1, February 2014, pp. 18-29.
####
For more information, please click here
Copyright © Fars News Agency
If you have a comment, please Contact us.Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.
Bookmark:
| Related News Press |
News and information
Sensors innovations for smart lithium-based batteries: advancements, opportunities, and potential challenges August 8th, 2025
Deciphering local microstrain-induced optimization of asymmetric Fe single atomic sites for efficient oxygen reduction August 8th, 2025
Lab to industry: InSe wafer-scale breakthrough for future electronics August 8th, 2025
Chemistry
Cambridge chemists discover simple way to build bigger molecules – one carbon at a time June 6th, 2025
Single-atom catalysts change spin state when boosted by a magnetic field June 4th, 2025
Quantum interference in molecule-surface collisions February 28th, 2025
Chainmail-like material could be the future of armor: First 2D mechanically interlocked polymer exhibits exceptional flexibility and strength January 17th, 2025
Nanomedicine
New molecular technology targets tumors and simultaneously silences two ‘undruggable’ cancer genes August 8th, 2025
New imaging approach transforms study of bacterial biofilms August 8th, 2025
Cambridge chemists discover simple way to build bigger molecules – one carbon at a time June 6th, 2025
Electrifying results shed light on graphene foam as a potential material for lab grown cartilage June 6th, 2025
Discoveries
Deciphering local microstrain-induced optimization of asymmetric Fe single atomic sites for efficient oxygen reduction August 8th, 2025
ICFO researchers overcome long-standing bottleneck in single photon detection with twisted 2D materials August 8th, 2025
New molecular technology targets tumors and simultaneously silences two ‘undruggable’ cancer genes August 8th, 2025
Simple algorithm paired with standard imaging tool could predict failure in lithium metal batteries August 8th, 2025
Announcements
Sensors innovations for smart lithium-based batteries: advancements, opportunities, and potential challenges August 8th, 2025
Deciphering local microstrain-induced optimization of asymmetric Fe single atomic sites for efficient oxygen reduction August 8th, 2025
Japan launches fully domestically produced quantum computer: Expo visitors to experience quantum computing firsthand August 8th, 2025
ICFO researchers overcome long-standing bottleneck in single photon detection with twisted 2D materials August 8th, 2025
Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers/Posters
New molecular technology targets tumors and simultaneously silences two ‘undruggable’ cancer genes August 8th, 2025
Simple algorithm paired with standard imaging tool could predict failure in lithium metal batteries August 8th, 2025
First real-time observation of two-dimensional melting process: Researchers at Mainz University unveil new insights into magnetic vortex structures August 8th, 2025
Lab to industry: InSe wafer-scale breakthrough for future electronics August 8th, 2025
 |
||
 |
||
| The latest news from around the world, FREE | ||
 |
||
|
|
||
| Premium Products | ||
 |
||
|
Only the news you want to read!
Learn More |
||
 |
||
|
Full-service, expert consulting
Learn More |
||
|
|
||