Home > Press > Immunomodulatory effect of nanoparticles
 |
Abstract:
Polymeric nanoparticles for immunotherapy represent a dynamic research field. The possibility to control their size, charge, and other surface properties provides the opportunity to affect both uptake by immune cells and induction of immunity. Dendritic cells (DC), which represent the most potent antigen-presenting cells of the immune system, are one of the main targets of current NP-based immunotherapeutic approaches against tumors.
Immunomodulatory effect of nanoparticles
Mainz, Germany | Posted on October 25th, 2012Researcher from the Max Planck Institute for Polymer Research in Mainz, Germany, now study the uptake of unfunctionalized, sulfonate- and phosphonate-functionalized polystyrene NP by immature DC (iDC) and mature DC (mDC). iDC display a higher time- and dose-dependent uptake of functionalized polystyrene NP mDC. Notably, NP induce an enhanced maturation of iDC resulting in a significantly enhanced T cell stimulatory capacity.
Considering the increasing use of nanomaterials in clinical studies, investigations on the effect of nanomaterials on cell morphology and functionality are critical for screening materials that can potentially be used in clinical settings. The results are important for the research on immunomodulatory properties of NP and their potential applications in immunotherapy.
####
For more information, please click here
Copyright © Wiley-VCH Materials Science Journals
If you have a comment, please Contact us.Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.
Bookmark:
| Related Links |
Link to the original paper on Wiley Online Library:
| Related News Press |
News and information
Sensors innovations for smart lithium-based batteries: advancements, opportunities, and potential challenges August 8th, 2025
Deciphering local microstrain-induced optimization of asymmetric Fe single atomic sites for efficient oxygen reduction August 8th, 2025
Lab to industry: InSe wafer-scale breakthrough for future electronics August 8th, 2025
Nanomedicine
New molecular technology targets tumors and simultaneously silences two ‘undruggable’ cancer genes August 8th, 2025
New imaging approach transforms study of bacterial biofilms August 8th, 2025
Cambridge chemists discover simple way to build bigger molecules – one carbon at a time June 6th, 2025
Electrifying results shed light on graphene foam as a potential material for lab grown cartilage June 6th, 2025
Discoveries
Deciphering local microstrain-induced optimization of asymmetric Fe single atomic sites for efficient oxygen reduction August 8th, 2025
ICFO researchers overcome long-standing bottleneck in single photon detection with twisted 2D materials August 8th, 2025
New molecular technology targets tumors and simultaneously silences two ‘undruggable’ cancer genes August 8th, 2025
Simple algorithm paired with standard imaging tool could predict failure in lithium metal batteries August 8th, 2025
Announcements
Sensors innovations for smart lithium-based batteries: advancements, opportunities, and potential challenges August 8th, 2025
Deciphering local microstrain-induced optimization of asymmetric Fe single atomic sites for efficient oxygen reduction August 8th, 2025
Japan launches fully domestically produced quantum computer: Expo visitors to experience quantum computing firsthand August 8th, 2025
ICFO researchers overcome long-standing bottleneck in single photon detection with twisted 2D materials August 8th, 2025
 |
||
 |
||
| The latest news from around the world, FREE | ||
 |
||
|
|
||
| Premium Products | ||
 |
||
|
Only the news you want to read!
Learn More |
||
 |
||
|
Full-service, expert consulting
Learn More |
||
|
|
||