Nanotechnology Now

Our NanoNews Digest Sponsors
Heifer International



Home > Press > MRI images transplanted islet cells with help of positively charged nanoparticles

Abstract:
In a study to investigate the detection by MRI of six kinds of positively-charged magnetic iron oxide nanoparticles designed to help monitor transplanted islet cells, a team of Japanese researchers found that the charged nanoparticles they developed transduced into cells and could be visualized by MRI while three kinds of commercially available nanoparticles used for controls could not. The study is published in a recent special issue of Cell Medicine [3(1)], now freely available on-line at: www.ingentaconnect.com/content/cog/cm.

MRI images transplanted islet cells with help of positively charged nanoparticles

Tampa, FL | Posted on October 1st, 2012

"Our data suggests that novel, positively-charged nanoparticles can be useful MRI contrast agents to monitor islet mass after transplantation," said study co-author Hirofumi Noguchi, MD, PhD, of the Department of Gastroenterological Surgery, transplant and Surgical Oncology at the Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences. "Significant graft loss immediately after islet transplantation occurs due to immunological and non-immunological events. With MRI an attractive potential tool for monitoring islet mass in vivo, efficient uptake of MRI contrast agent is required for cell labeling."

The researchers note that recent techniques of labeling islet cells with magnetic iron oxide has allowed detection of transplanted islet cells, however commercially available magnetic nanoparticles are not efficiently transduced because the cell surface is negatively charged and the negative charge of the nanoparticles. The researchers developed positively charged nanoparticles that were efficiently transduced.

"This approach could potentially be translated into clinical practice for evaluating graft survival and for monitoring therapeutic intervention during graft rejection," concluded Dr. Noguchi.

This research was among those studies presented at the 37th Annual Meeting of the Japan Society for Organ Preservation and Medical Biology (JSOPMB). Sixteen studies were published in this special issue of Cell Medicine. The theme of the issue is "Organ/Cell Transplantation and Regenerative Medicine."

Citation. Oishi, K.; Noguchi, H.; Saito, H.; Yukawa, H.; Miyamoto, Y.; Ono, K.; Murase, K.; Sawada, M.; Hayashi, S. Novel positive-charged nanoparticles for efficient magnetic resonance imaging of islet transplantation. Cell Med. 3(1):43-49; 2012.

####

For more information, please click here

Contacts:
The editorial offices for Cell Medicine
are at the Center of Excellence for
Aging and Brain Repair
College of Medicine
The University of South Florida
Contact:
David Eve


Dr. Hirofumi Noguchi
Department of Gastroenterological Surgery
Transplant and Surgical Oncology
Okayama University Graduate School of Medicine
Dentistry and Pharmaceutical Sciences
2-5-1 Shikata
Okayama 700-8558 Japan
Tel + 81-86-235-7257
Fax + 81-86-221-8775

Copyright © Cell Transplantation Center of Excellence for Aging and Brai

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

INRS and ELI deepen strategic partnership to train the next generation in laser science:PhD students will benefit from international mobility and privileged access to cutting-edge infrastructure June 6th, 2025

Electrifying results shed light on graphene foam as a potential material for lab grown cartilage June 6th, 2025

Quantum computers simulate fundamental physics: shedding light on the building blocks of nature June 6th, 2025

A 1960s idea inspires NBI researchers to study hitherto inaccessible quantum states June 6th, 2025

Imaging

New material to make next generation of electronics faster and more efficient With the increase of new technology and artificial intelligence, the demand for efficient and powerful semiconductors continues to grow November 8th, 2024

Turning up the signal November 8th, 2024

New discovery aims to improve the design of microelectronic devices September 13th, 2024

Quantum researchers cause controlled ‘wobble’ in the nucleus of a single atom September 13th, 2024

Nanomedicine

Ben-Gurion University of the Negev researchers several steps closer to harnessing patient's own T-cells to fight off cancer June 6th, 2025

Cambridge chemists discover simple way to build bigger molecules – one carbon at a time June 6th, 2025

Electrifying results shed light on graphene foam as a potential material for lab grown cartilage June 6th, 2025

Self-propelled protein-based nanomotors for enhanced cancer therapy by inducing ferroptosis June 6th, 2025

Discoveries

Researchers unveil a groundbreaking clay-based solution to capture carbon dioxide and combat climate change June 6th, 2025

Cambridge chemists discover simple way to build bigger molecules – one carbon at a time June 6th, 2025

Electrifying results shed light on graphene foam as a potential material for lab grown cartilage June 6th, 2025

A 1960s idea inspires NBI researchers to study hitherto inaccessible quantum states June 6th, 2025

Announcements

INRS and ELI deepen strategic partnership to train the next generation in laser science:PhD students will benefit from international mobility and privileged access to cutting-edge infrastructure June 6th, 2025

Electrifying results shed light on graphene foam as a potential material for lab grown cartilage June 6th, 2025

Quantum computers simulate fundamental physics: shedding light on the building blocks of nature June 6th, 2025

A 1960s idea inspires NBI researchers to study hitherto inaccessible quantum states June 6th, 2025

Tools

Portable Raman analyzer detects hydrogen leaks from a distance: Device senses tiny concentration changes of hydrogen in ambient air, offering a dependable way to detect and locate leaks in pipelines and industrial systems April 25th, 2025

Rice researchers harness gravity to create low-cost device for rapid cell analysis February 28th, 2025

New 2D multifractal tools delve into Pollock's expressionism January 17th, 2025

New material to make next generation of electronics faster and more efficient With the increase of new technology and artificial intelligence, the demand for efficient and powerful semiconductors continues to grow November 8th, 2024

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project