Home > Press > Antibacterial Nanoparticles Prove More Efficient than Gentamicin in Fighting Infections
Abstract:
A multidisciplinary and multinational research group consisted of researchers from the University of Tehran, Iran, University of Mons, Belgium, University of Groningen and University of Twente, the Netherlands, carefully investigated the antibacterial behavior of magnetic iron oxide nanoparticles and demonstrated their efficacy as biocompatible antibacterial agents.
Antibacterial Nanoparticles Prove More Efficient than Gentamicin in Fighting Infections
Tehran, Iran | Posted on August 7th, 2012In order to overcome the shortcomings of the commonly prescribed antibiotics in the treatment of infections caused by implanted biomaterials, the researchers devised an external magnetic field to guide the mentioned nanoparticles towards the grown bacterial colonies through a targeted drug delivery approach. By doing so, a multiple-fold higher antibacterial activity, compared with gentamicin, was achieved.
"As the initial part of our research, we carried out a feasibility study on the use of SPOINs (superparamagnetic iron oxide nanoparticles) as bactericide agents. The idea was triggered by the fact that most of metal nanoparticles exhibit antibacterial characteristics. Although their applicability is hindered by their potential toxicities, SPOINs are found to kill only the bacteria and being harmless to human body cells," Dr. Shahriar Sharifi, member of the research group, explained.
"Bearing the special magnetic properties of the SPOINs in mind, we tried to direct these nanoparticles to the locations of the bacterial colonies by exerting an external magnetic field. In this way, we came up with considerably increased and deeper penetration of the nanoparticles into the formed biofilms. These diffused SPOINs later generate reactive oxygen species (ROS), thanks to their nanometric dimensions as small as 5 nm, which damage the bacterial cell walls resulting in their death." Dr. Sharifi said, explaining about the mechanism of antibacterial activity of the SPIONs.
The results of this research work have been published in detail in Acta Biomaterialia.
####
For more information, please click here
Copyright © Fars News Agency
If you have a comment, please Contact us.Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.
Bookmark:
| Related News Press |
News and information
Quantum computer improves AI predictions April 17th, 2026
Flexible sensor gains sensitivity under pressure April 17th, 2026
A reusable chip for particulate matter sensing April 17th, 2026
Detecting vibrational quantum beating in the predissociation dynamics of SF6 using time-resolved photoelectron spectroscopy April 17th, 2026
Nanomedicine
A fundamentally new therapeutic approach to cystic fibrosis: Nanobody repairs cellular defect April 17th, 2026
New molecular technology targets tumors and simultaneously silences two ‘undruggable’ cancer genes August 8th, 2025
New imaging approach transforms study of bacterial biofilms August 8th, 2025
Electrifying results shed light on graphene foam as a potential material for lab grown cartilage June 6th, 2025
Discoveries
Quantum computer improves AI predictions April 17th, 2026
Flexible sensor gains sensitivity under pressure April 17th, 2026
A reusable chip for particulate matter sensing April 17th, 2026
Detecting vibrational quantum beating in the predissociation dynamics of SF6 using time-resolved photoelectron spectroscopy April 17th, 2026
Announcements
A fundamentally new therapeutic approach to cystic fibrosis: Nanobody repairs cellular defect April 17th, 2026
UC Irvine physicists discover method to reverse ‘quantum scrambling’ : The work addresses the problem of information loss in quantum computing system April 17th, 2026
Nanobiotechnology
A fundamentally new therapeutic approach to cystic fibrosis: Nanobody repairs cellular defect April 17th, 2026
New molecular technology targets tumors and simultaneously silences two ‘undruggable’ cancer genes August 8th, 2025
New imaging approach transforms study of bacterial biofilms August 8th, 2025
Electrifying results shed light on graphene foam as a potential material for lab grown cartilage June 6th, 2025
Research partnerships
Lab to industry: InSe wafer-scale breakthrough for future electronics August 8th, 2025
HKU physicists uncover hidden order in the quantum world through deconfined quantum critical points April 25th, 2025
 |
||
 |
||
| The latest news from around the world, FREE | ||
 |
||
|
|
||
| Premium Products | ||
 |
||
|
Only the news you want to read!
Learn More |
||
 |
||
|
Full-service, expert consulting
Learn More |
||
|
|
||