Nanotechnology Now

Our NanoNews Digest Sponsors
Heifer International



Home > Press > Hand-held NMR Instrument Yields Rapid Analysis of Human Tumors

Abstract:
Using a handheld molecular imaging device in combination with magnetic nanoparticles and a smartphone, a team of investigators from the Massachusetts General Hospital and Harvard Medical School has developed a fast, portable and potentially inexpensive method of detecting cancer from human biopsy samples. Initial results obtained using fine need biopsies taken from human cancer patients show this device trumps traditional pathological methods, both in terms of speed and diagnostic accuracy.

Hand-held NMR Instrument Yields Rapid Analysis of Human Tumors

Bethesda, MD | Posted on March 26th, 2011

Ralph Weissleder, co-principal investigator of the MIT-Harvard Center for Cancer Nanotechnology Excellence, led this development project. He and his colleagues published the results of their work in the journal Science Translational Medicine.

Typically, cancer is diagnosed by collecting human tissue samples, either removed surgically or via a fine needle inserted into a lump, and sending the samples to a histopathology laboratory, where over the course of several days the sample is analyzed using various tissue stains that highlight cellular features characteristic of tumors for visualization under a microscope. Such analysis is not only time-consuming, it is semi-quantitative at best and requires the technical expertise of a trained pathologist.

The new approach to cancer diagnosis pioneered by Dr. Weissleder and his collaborators relies on the exquisite sensitivity afforded by nuclear magnetic resonance spectroscopy (NMR), an analytical technique used routinely by chemists to characterize complex molecules and one that forms the basis of magnetic resonance imaging (MRI). But rather than using a standard, table-sized NMR machine, the Mass General team designed and built a far-less-expensive handheld NMR machine that interfaces with a microfluidic device and sends its results to a smartphone, which is also used to control the device. The device can detect the presence of multiple magnetic nanoparticles, each designed to bind to a specific tumor-associated molecular marker.

In the first round of evaluation, the investigators analyzed fine needle biopsies taken from 50 patients suspected of having malignant abdominal tumors. After a quick preparatory step, the suspension of cells from the biopsy was treated with a mixture of magnetic nanoparticles, each designed to bind to one of nine specific cancer biomarkers, and then injected into the device's microfluidic channels. Data signals from the microNMR machine were sent wirelessly to a smartphone for analysis and readout. The instrument correctly identified all 44 samples diagnosed as malignant by standard histopathology.

Based on the data generated in this first set of experiments, the investigators analyzed fine needle biopsies from an additional 20 patients using just four of the tagged nanoparticles. The results from this experiment were even better, demonstrating 96% diagnostic accuracy, far exceeding the 84% accuracy of histopathology, the gold standard of cancer diagnosis. Moreover, the microNMR-smartphone device provides a diagnosis within an hour, compared to three days to obtain results from histopathology.

####

About The National Cancer Institute (NCI)
The NCI Alliance for Nanotechnology in Cancer is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat, and prevent cancer. Through its programs and initiatives, the Alliance is committed to building a community of researchers dedicated to using nanotechnology to advance the fight against cancer.

As part of the Center for Strategic Scientific Initiatives, the Alliance for Nanotechnology in Cancer works in concert with other NCI advanced technology initiatives to provide the scientific foundation and team science that is required to transform cancer research and care.

For more information, please click here

Contacts:
National Cancer Institute
Center for Strategic Scientific Initiatives
NCI Office of Cancer Nanotechnology Research (OCNR)
Building 31, Room 10A52
31 Center Drive, MSC 2580
Bethesda, MD 20892-2580
Telephone: (301) 451-8983

Copyright © The National Cancer Institute (NCI)

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

View abstract - "Micro-NMR for Rapid Molecular Analysis of Human Tumor Samples."

Related News Press

News and information

New class of protein misfolding simulated in high definition: Evidence for recently identified and long-lasting type of protein misfolding bolstered by atomic-scale simulations and new experiments August 8th, 2025

Sensors innovations for smart lithium-based batteries: advancements, opportunities, and potential challenges August 8th, 2025

Deciphering local microstrain-induced optimization of asymmetric Fe single atomic sites for efficient oxygen reduction August 8th, 2025

Lab to industry: InSe wafer-scale breakthrough for future electronics August 8th, 2025

Imaging

ICFO researchers overcome long-standing bottleneck in single photon detection with twisted 2D materials August 8th, 2025

Simple algorithm paired with standard imaging tool could predict failure in lithium metal batteries August 8th, 2025

First real-time observation of two-dimensional melting process: Researchers at Mainz University unveil new insights into magnetic vortex structures August 8th, 2025

Nanomedicine

New molecular technology targets tumors and simultaneously silences two ‘undruggable’ cancer genes August 8th, 2025

New imaging approach transforms study of bacterial biofilms August 8th, 2025

Cambridge chemists discover simple way to build bigger molecules – one carbon at a time June 6th, 2025

Electrifying results shed light on graphene foam as a potential material for lab grown cartilage June 6th, 2025

Discoveries

Deciphering local microstrain-induced optimization of asymmetric Fe single atomic sites for efficient oxygen reduction August 8th, 2025

ICFO researchers overcome long-standing bottleneck in single photon detection with twisted 2D materials August 8th, 2025

New molecular technology targets tumors and simultaneously silences two ‘undruggable’ cancer genes August 8th, 2025

Simple algorithm paired with standard imaging tool could predict failure in lithium metal batteries August 8th, 2025

Announcements

Sensors innovations for smart lithium-based batteries: advancements, opportunities, and potential challenges August 8th, 2025

Deciphering local microstrain-induced optimization of asymmetric Fe single atomic sites for efficient oxygen reduction August 8th, 2025

Japan launches fully domestically produced quantum computer: Expo visitors to experience quantum computing firsthand August 8th, 2025

ICFO researchers overcome long-standing bottleneck in single photon detection with twisted 2D materials August 8th, 2025

Tools

Japan launches fully domestically produced quantum computer: Expo visitors to experience quantum computing firsthand August 8th, 2025

Portable Raman analyzer detects hydrogen leaks from a distance: Device senses tiny concentration changes of hydrogen in ambient air, offering a dependable way to detect and locate leaks in pipelines and industrial systems April 25th, 2025

Rice researchers harness gravity to create low-cost device for rapid cell analysis February 28th, 2025

New 2D multifractal tools delve into Pollock's expressionism January 17th, 2025

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project