Home > Press > Magnetic Field Directs Nanoparticles to Tumors
![]() |
Abstract:
To improve the tumor-specific delivery of drug to tumors, a team of investigators from the University of California, San Diego (UCSD) has created a system of nanoparticles-within-a-nanoparticle that can be directed to and concentrated at the site of tumor using a magnetic field. Once at the tumor site, radiofrequency irradiation triggers drug release from the nanoparticles, bathing the tumors in drug and markedly reducing the growth of the tumors.
Reporting its work in the journal Nano Letters, a research team led by Sungho Jin described the multiple steps it uses to create these multi-component nanoparticles that contain both magnetic nanoparticles and the drug Camptothecin trapped within a silica shell. Trapped within the silica nanoparticle, the close proximity of the hundreds of magnetic iron oxide nanoparticles boosts their responsiveness to a magnetic field applied from outside the body. More importantly, at moderate magnetic field strengths the nanoparticles not only accumulate in the vicinity of a tumor but also penetrate into the tumor mass.
Based on these initial results, the investigators injected the nanoparticles into mice implanted with human breast tumors. After using a magnetic field to direct the nanoparticles to tumors during a two-hour period, the researchers subjected the animals to three 8-minute exposures to radiofrequency irradiation. The treated animals experienced a marked reduction in the size of their tumors and experienced no noticeable side effects.
####
About The National Cancer Institute (NCI)
The NCI Alliance for Nanotechnology in Cancer is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.
The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.
Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.
For more information, please click here
Contacts:
National Cancer Institute
Center for Strategic Scientific Initiatives
ATTN: NCI Office of Cancer Nanotechnology Research (OCNR)
Building 31, Room 10A52
31 Center Drive, MSC 2580
Bethesda, MD 20892-2580
(301) 451-8983
Copyright © The National Cancer Institute (NCI)
If you have a comment, please Contact us.Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.
Related Links |
Related News Press |
News and information
Electrifying results shed light on graphene foam as a potential material for lab grown cartilage June 6th, 2025
Quantum computers simulate fundamental physics: shedding light on the building blocks of nature June 6th, 2025
A 1960s idea inspires NBI researchers to study hitherto inaccessible quantum states June 6th, 2025
Imaging
Turning up the signal November 8th, 2024
New discovery aims to improve the design of microelectronic devices September 13th, 2024
Quantum researchers cause controlled ‘wobble’ in the nucleus of a single atom September 13th, 2024
Govt.-Legislation/Regulation/Funding/Policy
Electrifying results shed light on graphene foam as a potential material for lab grown cartilage June 6th, 2025
Institute for Nanoscience hosts annual proposal planning meeting May 16th, 2025
Rice researchers harness gravity to create low-cost device for rapid cell analysis February 28th, 2025
Nanomedicine
Ben-Gurion University of the Negev researchers several steps closer to harnessing patient's own T-cells to fight off cancer June 6th, 2025
Cambridge chemists discover simple way to build bigger molecules – one carbon at a time June 6th, 2025
Electrifying results shed light on graphene foam as a potential material for lab grown cartilage June 6th, 2025
Self-propelled protein-based nanomotors for enhanced cancer therapy by inducing ferroptosis June 6th, 2025
Discoveries
Researchers unveil a groundbreaking clay-based solution to capture carbon dioxide and combat climate change June 6th, 2025
Cambridge chemists discover simple way to build bigger molecules – one carbon at a time June 6th, 2025
Electrifying results shed light on graphene foam as a potential material for lab grown cartilage June 6th, 2025
A 1960s idea inspires NBI researchers to study hitherto inaccessible quantum states June 6th, 2025
Announcements
Electrifying results shed light on graphene foam as a potential material for lab grown cartilage June 6th, 2025
Quantum computers simulate fundamental physics: shedding light on the building blocks of nature June 6th, 2025
A 1960s idea inspires NBI researchers to study hitherto inaccessible quantum states June 6th, 2025
![]() |
||
![]() |
||
The latest news from around the world, FREE | ||
![]() |
![]() |
||
Premium Products | ||
![]() |
||
Only the news you want to read!
Learn More |
||
![]() |
||
Full-service, expert consulting
Learn More |
||
![]() |