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Image shows phenytoin before (x10,000) and after (x100,000) thinky mixing

Abstract:
Thinky mixers from Intertronics create nano-particle suspensions of medical compounds more reliably and quicker than traditional methods

Nano-particle suspension in pharmaceutical mixing

UK | Posted on May 11th, 2010

A new clever mixing process is announced by the people at Intertronics using the Thinky ARV-310 and Thinky ARV-5000 industrial non-contact "planetary" mixers for engineering compounds. In particular these machines are excellent in creating nano-particle suspensions of medical compounds more reliably and quicker than traditional methods. This can often overcome problems of dilution where materials have negligible water solubility and they enable mixing, dispersal and degassing in amounts as small as 0.5ml, up to large, laboratory level quantities.

The new process involves use of a Thinky mixer with zirconia balls which can pulverize poorly water soluble compounds such as medical drug doses using the over 2000 rpm planetary technology. In addition use of the ARV vacuum mixer enables complete elimination of all air bubbles. Commonly a pestle and mortar are used for oral dosage formulations. While this method is generally accepted and effective, this hand process is tedious and tiring, and lacks any degree of repeatability or consistent quality. The new technique is called "nh-Step". The nh-Step makes the mixing process easy, fast, improves physiochemical properties and it can be applied to many oral suspensions. For example, with an initial particle size of 18 micron, utilizing the "nh-Step" process the particle distribution was reduced to 2 microns after only 3 minutes with the Thinky's ARE-250.

The Thinky ARV-310 and Thinky ARV-5000 have the ability to process under vacuum, or under normal pressure, or even automatically switching into vacuum mode from non-vacuum state during the process. It is possible to set the desired vacuum level for different types of ingredients. For high-viscosity materials and materials for which a high degree of de-aeration is required, these are ideal mixers. These mixers can eliminate micron-sized bubbles, without the danger of foaming and messy spillage.

Further information regarding Intertronics' products can be found at www.intertronics.co.uk.

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