Home > News > White light microscope
March 1st, 2009
White light microscope
Abstract:
Silver nanoparticles that can generate white light could improve microscopy in research into cancer and bone diseases according to a paper in the March issue of Nano Letters.
Optical microscopy is commonly thought to use optical transmission measurements, whereas most modern microscopists working with contemporary high-resolution microscopes use fluorescence. But, fluorescence has its limitations.
Powerful as it is, fluorescence microscopy has a fatal flaw - the need to treat any specimen with fluorescent dyes or stains. The application of these dyes often alters or harms tissues and can kill living cells. So, although fluorescence microscopy is unsurpassed in acquisition speed and spatial resolution it is severely limited in this sense.
John Lupton and colleagues, Debansu Chaudhuri, Jeremy Galushs, Manfred Walter, Nicholas Borys, and Michael Bartl in the Department of Physics and Department of Chemistry, at the University of Utah, Salt Lake City, hope to circumvent this problem without resorting to old-style microscopy.
They have worked clusters of silver nanoparticles. Silver nanoparticle films have been used for single molecule surface-enhanced Raman scattering (SERS) studies before with one- or two-photon excitation. They can thus act as a tuneable beacon of light for transmission microscopy carried out at resolutions below the diffraction limit. This limit normally stymies conventional microscopy. The researchers suggest that their success could allow researchers to investigate cancerous tissues, diseased bone and other diffuse materials in unprecedented detail and without dyes to damage the sample.
Source:
spectroscopynow.com
Bookmark:
| Related News Press |
News and information
Sensors innovations for smart lithium-based batteries: advancements, opportunities, and potential challenges August 8th, 2025
Deciphering local microstrain-induced optimization of asymmetric Fe single atomic sites for efficient oxygen reduction August 8th, 2025
Lab to industry: InSe wafer-scale breakthrough for future electronics August 8th, 2025
Imaging
ICFO researchers overcome long-standing bottleneck in single photon detection with twisted 2D materials August 8th, 2025
Simple algorithm paired with standard imaging tool could predict failure in lithium metal batteries August 8th, 2025
First real-time observation of two-dimensional melting process: Researchers at Mainz University unveil new insights into magnetic vortex structures August 8th, 2025
Discoveries
Deciphering local microstrain-induced optimization of asymmetric Fe single atomic sites for efficient oxygen reduction August 8th, 2025
ICFO researchers overcome long-standing bottleneck in single photon detection with twisted 2D materials August 8th, 2025
New molecular technology targets tumors and simultaneously silences two ‘undruggable’ cancer genes August 8th, 2025
Simple algorithm paired with standard imaging tool could predict failure in lithium metal batteries August 8th, 2025
Announcements
Sensors innovations for smart lithium-based batteries: advancements, opportunities, and potential challenges August 8th, 2025
Deciphering local microstrain-induced optimization of asymmetric Fe single atomic sites for efficient oxygen reduction August 8th, 2025
Japan launches fully domestically produced quantum computer: Expo visitors to experience quantum computing firsthand August 8th, 2025
ICFO researchers overcome long-standing bottleneck in single photon detection with twisted 2D materials August 8th, 2025
Tools
Japan launches fully domestically produced quantum computer: Expo visitors to experience quantum computing firsthand August 8th, 2025
Rice researchers harness gravity to create low-cost device for rapid cell analysis February 28th, 2025
New 2D multifractal tools delve into Pollock's expressionism January 17th, 2025
 |
||
 |
||
| The latest news from around the world, FREE | ||
 |
||
|
|
||
| Premium Products | ||
 |
||
|
Only the news you want to read!
Learn More |
||
 |
||
|
Full-service, expert consulting
Learn More |
||
|
|
||