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November 11th, 2008
Slipping past mucus for drug delivery
Abstract:
Mucus, while slimy and a bit unpleasant, forms a protective barrier for the surfaces of our eyes, respiratory tracts, gastrointestinal systems, and other vital parts. In preventing the penetration of various toxins, fine particles, and pathogens, mucus also blocks potentially therapeutic nanoparticles, making it very difficult to deliver drugs and gene therapy through mucosal surfaces. Viruses, on the other hand, have little trouble passing right through due to their outer coating. Scientists have tried to mimic this slippery coating by covering nanoparticles with PEG (poly(ethylene glycol)), a commonly used polymer that can vary in molecular weight depending on the length of its chain.
Source:
arstechnica.com
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