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August 13th, 2008

Fluorescent Genetic Barcodes

Abstract:
The capacity to track gene expression has been one of the biotechnology revolution's driving forces, so a technology that gives researchers more accuracy and sensitivity has the potential to lead to even more rapid progress. Dr Krassen Dimitrov of the Australasian Institute of Bioengineering and Nanotechnology at the University of Queensland has created what he calls "nanostrings". These are fluorescent pieces of nucleic acid that act like barcodes, binding to RNA molecules and providing researchers with an easy-to- read measure of the presence of biomolecules.

The technology has several advantages over the microarrays used currently. It provides a digital count, recording the exact number of RNA molecules, rather than an analogue result, where the correspondence between luminosity and the amount of molecules breaks down at high and low values. "Because this system can count the exact number of biomolecules present we can get an extremely accurate and sensitive picture of gene expression at a particular point in time," Dimitrov says.

Source:
redorbit.com

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