October 15th, 2007
Enzyme Humility
Abstract:
Enzymes use a variety of effects to work these wonders, but a lot of it comes down to holding the reacting species in one place and lining everything up perfectly. It isn't as important to hold on to the starting materials or products, as it is to interact with and stabilize the highest-energy species in the whole process, the fleeting transition state. Various chemical groups can be brought to bear that activate or deactivate specific bonds, and everything works, at its best, with near-perfect timing. If you want molecular level-nanotechnology, this is it, and there's absolutely no reason why it has to be done inside a peptide backbone. If we understood enough, all sorts of other polymers, with all sorts of new functionality built into them, could presumably do things that Nature has never needed to do, under conditions that we could select for.
Source:
pipeline.corante.com
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