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October 19th, 2006

New potent nanoassemblies to fight cancer and HIV

Abstract:
Professor Patrick Couvreur, director of the Physico-chimie, Pharmacotechnie et Biopharmacie department at the Université de Paris-Sud, and a team of researchers from the Università degli Studi di Torino/Italy and the Laboratoire de Neurovirologie in Fontenay-aux-Roses/France, have discovered that the linkage of nucleoside analogues to squalenic acid ("squalenization"), the acyclic isoprenoid chain of squalene, leads to squalenic amphiphilic prodrugs which self-organize in water as nanoassemblies of 100-300 nm, irrespective of the nucleoside analogue used and the location of covalent linkage.

Source:
nanowerk.com

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