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February 28th, 2006

Bismuth Nanoparticles Yield Promising X-ray Imaging Agent

Abstract:
... a team of researchers led by Ralph Weissleder, M.D., Ph.D., at Massachusetts General Hospital and Harvard Medical School, began their work by refining a method for growing bismuth sulphide nanocrystals to produce flat, rectangular particles of reproducible size and shape. They then coated the resulting nanocrystal with the biocompatible polymer poly(vinylpyrrolidone), or PVP, to create nanoparticles that would be inert in the body, absorb X-rays efficiently, and remain long enough to accumulate in the tumor, and thus, be more visible in a CT image. The researchers note that the PVP coating should also enable them to add tumor-targeting molecules to the particles to increase their ability to image small tumors.

Source:
nano.cancer.gov

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